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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.
Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.
Common side effects include headaches and heartburn, as well as flushed skin.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-counter sales of Viagra in stores in Manchester, England.