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Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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By using this site, you agree to the Terms of Use and Privacy Policy.The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

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Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Viagra at The Periodic Table of Videos (University of Nottingham).

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Common side effects include headaches and heartburn, as well as flushed skin.Learn about the potential side effects of Viagra (sildenafil).

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Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

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Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.

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This page of the eMedTV Web site briefly describes important safety concerns to.

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Includes common and rare side effects information for consumers and healthcare professionals.

There are also mouth spray preparations of sildenafil for faster onset of action.