The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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What links here Related changes Upload file Special pages Permanent link Page information Wikidata item Cite this page.Viagra Brand Name Viagra Common Name sildenafil In this drug factsheet: How does this medication work.

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Common side effects include headaches and heartburn, as well as flushed skin.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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pembesarpeniscepat.org.Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.Ams 700 Video How To Increase Penis Thickness with World Largest Natural Penis and Penispumps is the most frequent misfortune in the life.

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Caution is advised in those who have cardiovascular disease.Viagra (sildenafil) is used to treat erectile dysfunction or impotence in men.In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

Also, surf around Break to find the funniest videos, pictures and articles.The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).Drugs for erectile dysfunction ( G04BE ) and premature ejaculation.Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.This guy takes viagra and goes through TSA with a little something extra.Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.

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